PHTF1

Across TCGA patient cohorts, PHTF1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHTF1-associated genes across cancer lineages are Notch1, PRAS40_pT246, and IRS1. Each is linked with PHTF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHTF1-to-partner and partner-to-PHTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PHTF1-low versus PHTF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHTF1→partner) and Y-score (partner→PHTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.136	+3.013	.016	.018	3	2
UCEC	PRAS40_pT246 →	+0.185	+2.459	.007	.019	3	2
UCEC	IRS1 →	+0.184	+1.906	.027	.016	3	1
UCEC	JNK2 →	+0.198	+1.763	.013	.048	3	1
UCEC	MEK1 →	+0.331	+3.169	.024	.018	3	1
UCEC	p27_pT198 →	+0.128	+3.087	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Notch1 by PHTF1 expression — UCEC

Explore this box plot interactively →