PHTF1

Across TCGA pan-cancer cohorts, PHTF1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PHTF1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PHTF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PHTF1 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

BLCA, HNSC, and LIHC are the cancer types where PHTF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHTF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+1.131	<.001	11	view →
HNSC	Male	III,IV	+0.842	<.001	10	view →
LIHC	Female	III,IV	+1.041	<.001	8	view →
KICH	Female	II,III,IV	−0.961	<.001	8	view →
BRCA	All	III,IV	+0.650	<.001	8	view →
STAD	All	II,III,IV	+0.879	<.001	6	view →
UCEC	All	All	+0.593	.013	6	view →
CHOL	All	All	+1.753	<.001	5	view →
COAD	Male	All	+0.394	<.001	5	view →
LUSC	All	II,III,IV	−0.376	.001	4	view →
KIRP	All	IV	+0.859	.020	2	view →
LUAD	All	All	+0.189	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PHTF1–BLCA

Open the BLCA breakdown →