PHTF1

Across TCGA cell cohorts, PHTF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,680 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHTF1-associated GO terms across cancer lineages are Positive regulation of organelle assembly, Regulation of organelle assembly, and Negative regulation of post-translational protein modification. Each is linked with PHTF1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PHTF1-to-partner and partner-to-PHTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of organelle assembly grouped by PHTF1-low versus PHTF1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHTF1→partner) and Y-score (partner→PHTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.072	+1.086	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Regulation of organelle assembly →	+0.057	+1.245	.003	.008	3	12
LARGE_INTESTINE	Negative regulation of post-translational protein modification →	+0.063	+0.895	<.001	.001	3	11
SOFT_TISSUE	Protein localization to cytoskeleton →	+0.074	+0.936	<.001	<.001	3	11
OESOPHAGUS	Nuclear transport →	+0.081	+0.899	.001	.001	3	11
OESOPHAGUS	Nucleocytoplasmic transport →	+0.081	+0.899	.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,680 associations by consensus.

Positive regulation of organelle assembly by PHTF1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →