PHOX2B

Across TCGA pan-cancer cohorts, PHOX2B Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PHOX2B data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PHOX2B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PHOX2B expression acts as an unfavorable survival marker.

COAD, LUAD, and UCEC are the cancer types where PHOX2B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.001	0.871	<.001	13	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PHOX2B–COAD (OS)

Open the COAD breakdown →