PHOX2B

Across TCGA pan-cancer cohorts, PHOX2B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PHOX2B data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PHOX2B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PHOX2B expression acts as an unfavorable survival marker.

UCEC, HNSC, and LUAD are the cancer types where PHOX2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.638	1.000	.014	8	view →
HNSC	OS	Median	All	0.647	0.872	.017	7	view →
LUAD	DFS	Median	II,III,IV	0.211	0.705	.006	6	view →
CCRCC	DFS	Median	IV	0.164	0.861	.038	6	view →
PDAC	OS	Median	III,IV	0.431	0.988	.010	6	view →
LSCC	DFS	Median	II,III,IV	0.579	0.930	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PHOX2B–UCEC (OS)

Open the UCEC breakdown →