PHOX2B-AS1

Across TCGA pan-cancer cohorts, PHOX2B-AS1 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated PHOX2B-AS1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher PHOX2B-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PHOX2B-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and PAAD show a favorable association.

BLCA, KIRC, and UCEC are the cancer types where PHOX2B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	III,IV	0.172	0.555	<.001	90	view →
KIRC	DFS	Tertile	III,IV	0.285	0.651	.011	54	view →
UCEC	OS	Tertile	All	0.746	0.877	.008	36	view →
SARC	OS	Tertile	All	0.252	0.771	<.001	21	view →
ESCA	OS	Tertile	III,IV	1.000	0.372	.036	12	view →
PRAD	OS	Tertile	All	0.963	0.995	.013	12	view →
PAAD	DFS	Tertile	All	0.702	0.462	.032	9	view →
LGG	OS	Tertile	All	0.671	0.816	.026	9	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PHOX2B-AS1–BLCA (DFS)

Open the BLCA breakdown →