PHOX2B-AS1

Across TCGA pan-cancer cohorts, PHOX2B-AS1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PHOX2B-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where PHOX2B-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PHOX2B-AS1 is over-expressed in tumor, although a few such as STAD and COAD show the opposite, repressed pattern.

STAD, COAD, and READ are the cancer types where PHOX2B-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHOX2B-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	−0.161	.009	5	view →
COAD	All	All	−0.048	<.001	5	view →
READ	All	All	−0.146	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PHOX2B-AS1–STAD

Open the STAD breakdown →