PHOX2A

Across TCGA patient cohorts, PHOX2A RNA expression is significantly associated with the go_rna of many other GO terms, with 6,986 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PHOX2A-associated GO terms across cancer lineages are Negative regulation of growth, Somatic motor neuron differentiation, and Negative regulation of cell growth. Each is linked with PHOX2A in more than 15 cancer types. Because this analysis shows association rather than direction, both PHOX2A-to-partner and partner-to-PHOX2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of growth grouped by PHOX2A-low versus PHOX2A-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHOX2A→partner) and Y-score (partner→PHOX2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Negative regulation of growth →	+0.057	+0.493	<.001	.004	3	16
THYM	Somatic motor neuron differentiation →	-0.072	-0.191	<.001	<.001	3	15
ESCA	Negative regulation of cell growth →	+0.064	+0.464	<.001	.002	3	15
ESCA	Regulation of establishment of planar polarity →	+0.057	+0.322	<.001	.008	3	14
STAD	Positive regulation of Arp2/3 complex-mediated actin nucleation →	+0.057	+0.341	<.001	<.001	3	14
ESCA	Mesenchymal cell differentiation →	+0.061	+0.399	<.001	.002	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,986 associations by consensus.

Negative regulation of growth by PHOX2A expression — ESCA

Explore this box plot interactively →