PHOX2A

Across TCGA pan-cancer cohorts, PHOX2A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PHOX2A data layer compared with 2 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher PHOX2A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PHOX2A expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCS show a favorable association.

SCLC, ACC, and UVM are the cancer types where PHOX2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	All	0.699	0.429	<.001	66	view →
ACC	DFS	Tertile	II,III,IV	0.110	0.598	.002	55	view →
UVM	OS	Median	III,IV	0.293	0.870	.014	28	view →
LGG	DFS	Median	All	0.682	0.790	.002	26	view →
UCS	DFS	Tertile	IV	0.860	0.239	.024	24	view →
UCEC	OS	Tertile	IV	0.742	0.339	.018	24	view →
HNSC	DFS	Quartile	IV	0.849	0.483	.001	22	view →
LIHC	DFS	Tertile	All	0.429	0.559	.016	21	view →
READ	DFS	Tertile	IV	0.917	0.346	.004	18	view →
BLCA	DFS	Tertile	III,IV	0.474	0.579	.036	16	view →
CESC	DFS	Tertile	All	0.674	0.471	.017	16	view →
GBM	DFS	Median	All	0.318	0.207	.015	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PHOX2A–SCLC (DFS)

Open the SCLC breakdown →