PHOX2A

Across TCGA cell cohorts, PHOX2A mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PHOX2A-associated genes across cancer lineages are CFHR2, KRTAP4-5, and KRTAP4-2. Each is linked with PHOX2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PHOX2A-to-partner and partner-to-PHOX2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by PHOX2A-low versus PHOX2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHOX2A→partner) and Y-score (partner→PHOX2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.057	+5.022	<.001	.002	3	1
LUNG_SCLC	KRTAP4-5 →	+0.075	+5.029	<.001	.006	3	1
LUNG_SCLC	KRTAP4-2 →	+0.113	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CFHR2 by PHOX2A expression — LARGE_INTESTINE

Explore this box plot interactively →