PHOSPHO2

Across TCGA patient cohorts, PHOSPHO2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,060 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PHOSPHO2-associated genes across cancer lineages are BLOC1S5, TBC1D30, and FAM189A1. Each is linked with PHOSPHO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHOSPHO2-to-partner and partner-to-PHOSPHO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHOSPHO2 versus BLOC1S5 in UCEC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHOSPHO2→partner) and Y-score (partner→PHOSPHO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BLOC1S5 →	+0.607	+0.488	.001	<.001	3	2
BRCA	TBC1D30 →	+0.667	+0.594	<.001	<.001	3	2
UCEC	FAM189A1 →	-2.000	-0.453	.009	.005	3	1
UCEC	RAB2A →	+0.812	+0.405	.008	.008	3	1
UCEC	GCLC →	+1.056	+0.344	.003	.007	3	1
UCEC	CCN6 →	+2.420	+0.396	.009	.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,060 associations by consensus.

PHOSPHO2 vs BLOC1S5 — UCEC

Explore this scatter interactively →