PHLPP2

Across TCGA patient cohorts, PHLPP2 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,367 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PHLPP2-associated proteins across cancer lineages are PRKAA2_S377, ARL2BP, and TMEM154. Each is linked with PHLPP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHLPP2-to-partner and partner-to-PHLPP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHLPP2 versus PRKAA2_S377 in HNSC, with a Pearson correlation of 0.30.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLPP2→partner) and Y-score (partner→PHLPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRKAA2_S377 →	+0.809	+0.454	<.001	<.001	3	4
BRCA	ARL2BP →	+0.403	+0.568	<.001	<.001	3	4
HNSC	TMEM154 →	-0.779	-0.682	<.001	<.001	3	4
GBM	CD44_S686 →	-0.508	-0.354	.005	.006	3	4
CCRCC	CIAPIN1 →	+0.284	+0.390	<.001	<.001	3	4
LUAD	CIAPIN1_S183 →	+0.750	+0.499	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,367 associations by consensus.

PHLPP2 vs PRKAA2_S377 — HNSC

Explore this scatter interactively →