PHLPP1

Across TCGA patient cohorts, PHLPP1 mutation is significantly associated with the RNA expression of many other genes, with 5,295 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHLPP1-associated genes across cancer lineages are ATP5F1B, KIF20A, and CCNB1. Each is linked with PHLPP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHLPP1-to-partner and partner-to-PHLPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5F1B grouped by PHLPP1-low versus PHLPP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLPP1→partner) and Y-score (partner→PHLPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ATP5F1B →	+0.655	+3.613	<.001	.001	3	3
SKCM	KIF20A →	+0.892	+3.597	<.001	.001	3	3
SKCM	CCNB1 →	+0.595	+3.613	.009	.001	3	3
SKCM	KIF23 →	+0.701	+3.497	.005	.002	3	3
SKCM	KIF11 →	+0.751	+3.347	.006	.004	3	3
SKCM	BUB1B →	+0.927	+3.497	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,295 associations by consensus.

ATP5F1B by PHLPP1 expression — SKCM

Explore this box plot interactively →