PHLDB3

Across TCGA cell cohorts, PHLDB3 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHLDB3-associated genes across cancer lineages are LIPN, OR51E2, and OBP2A. Each is linked with PHLDB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHLDB3-to-partner and partner-to-PHLDB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIPN grouped by PHLDB3-low versus PHLDB3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB3→partner) and Y-score (partner→PHLDB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LIPN →	+0.032	+4.947	<.001	.001	3	3
SOFT_TISSUE	OR51E2 →	+0.300	+3.437	.003	.009	3	2
BLOOD_Leukemia	OBP2A →	+0.027	+3.984	<.001	.006	3	2
SOFT_TISSUE	ADAM30 →	+0.018	+3.297	<.001	.008	3	1
SOFT_TISSUE	OR7D4 →	+0.015	+3.977	<.001	.007	3	1
URINARY_TRACT	NXPE4 →	+0.007	+4.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

LIPN by PHLDB3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →