PHLDB2

Across TCGA patient cohorts, PHLDB2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,629 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PHLDB2-associated genes across cancer lineages are CALD1, FILIP1L, and COL5A2. Each is linked with PHLDB2 in more than 7 cancer types. Because this analysis shows association rather than direction, both PHLDB2-to-partner and partner-to-PHLDB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHLDB2 versus CALD1 in BRCA, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB2→partner) and Y-score (partner→PHLDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CALD1 →	+0.735	+0.333	<.001	<.001	3	8
BRCA	FILIP1L →	+0.903	+0.356	<.001	<.001	3	8
GBM	COL5A2 →	+1.232	+0.502	<.001	<.001	3	8
GBM	LGALS1 →	+1.008	+0.504	<.001	<.001	3	7
UCEC	FLT1 →	+0.712	+0.670	<.001	<.001	3	7
BRCA	CLEC11A →	+0.919	+0.323	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,629 associations by consensus.

PHLDB2 vs CALD1 — BRCA

Explore this scatter interactively →