PHLDB2

Across TCGA pan-cancer cohorts, PHLDB2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PHLDB2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PHLDB2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PHLDB2 is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where PHLDB2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHLDB2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+2.727	<.001	12	view →
LUAD	Female	II,III,IV	−1.374	<.001	8	view →
COAD	All	II,III,IV	−0.757	<.001	7	view →
UCEC	All	All	−1.945	<.001	6	view →
BRCA	All	All	−1.009	<.001	6	view →
KICH	All	All	−0.849	<.001	6	view →
LIHC	Male	II,III,IV	−0.825	.002	6	view →
BLCA	Male	All	−1.133	.035	4	view →
KIRC	All	II,III,IV	−0.410	.001	4	view →
READ	All	All	−1.433	.007	2	view →
KIRP	Male	All	−0.719	.002	2	view →
THCA	Male	All	+0.638	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PHLDB2–HNSC

Open the HNSC breakdown →