PHLDB2

Across TCGA patient cohorts, PHLDB2 mutation is significantly associated with the RNA expression of many other genes, with 6,695 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHLDB2-associated genes across cancer lineages are COX11, ORC1, and GPN3. Each is linked with PHLDB2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHLDB2-to-partner and partner-to-PHLDB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX11 grouped by PHLDB2-low versus PHLDB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB2→partner) and Y-score (partner→PHLDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX11 →	+0.396	+1.869	<.001	<.001	3	4
UCEC	ORC1 →	+0.683	+1.669	<.001	<.001	3	4
SKCM	GPN3 →	+0.399	+1.491	<.001	<.001	3	4
UCEC	ACAT2 →	+0.519	+1.562	<.001	.001	3	4
SKCM	ZFPL1 →	+0.249	+1.453	.001	<.001	3	4
SKCM	SMIM12 →	+0.297	+2.288	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,695 associations by consensus.

COX11 by PHLDB2 expression — UCEC

Explore this box plot interactively →