PHLDB2

Across TCGA patient cohorts, PHLDB2 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHLDB2-associated genes across cancer lineages are GAPDH, eIF4E, and CD49b. Each is linked with PHLDB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHLDB2-to-partner and partner-to-PHLDB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PHLDB2-low versus PHLDB2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB2→partner) and Y-score (partner→PHLDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	GAPDH →	+0.678	+3.169	<.001	.019	3	3
UCEC	eIF4E →	+0.175	+1.784	.003	<.001	3	3
SKCM	CD49b →	+0.192	+1.765	.003	.010	3	3
UCEC	4E-BP1 →	+0.333	+2.662	<.001	<.001	3	3
UCEC	Src_pY416 →	-0.156	-1.738	.022	.011	3	3
UCEC	VHL →	-0.619	-1.125	.001	.029	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

GAPDH by PHLDB2 expression — STAD

Explore this box plot interactively →