PHLDB2

Across TCGA cell cohorts, PHLDB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,312 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHLDB2-associated GO terms across cancer lineages are Protein activation cascade, Blood coagulation, fibrin clot formation, and Hemostasis. Each is linked with PHLDB2 in more than 12 cancer types. Because this analysis shows association rather than direction, both PHLDB2-to-partner and partner-to-PHLDB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein activation cascade grouped by PHLDB2-low versus PHLDB2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB2→partner) and Y-score (partner→PHLDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein activation cascade →	+0.381	+2.454	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Blood coagulation, fibrin clot formation →	+0.401	+2.432	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Hemostasis →	+0.147	+2.998	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Dentinogenesis →	+1.871	+2.622	<.001	.003	3	13
BREAST	Regulation of cell-substrate adhesion →	+0.096	+2.662	<.001	<.001	3	13
LIVER	Regulation of cell-matrix adhesion →	+0.109	+1.643	.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,312 associations by consensus.

Protein activation cascade by PHLDB2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →