PHLDB2

Across TCGA cell cohorts, PHLDB2 mutation is significantly associated with the RNA expression of many other genes, with 710 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHLDB2-associated genes across cancer lineages are NKX2-6, TTC19, and SRSF11. Each is linked with PHLDB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHLDB2-to-partner and partner-to-PHLDB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by PHLDB2-low versus PHLDB2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB2→partner) and Y-score (partner→PHLDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NKX2-6 →	+1.533	+4.544	<.001	.003	3	2
LARGE_INTESTINE	TTC19 →	+0.713	+3.169	<.001	.006	3	2
LARGE_INTESTINE	SRSF11 →	+0.637	+2.628	.007	.002	3	2
LARGE_INTESTINE	PRMT9 →	+0.489	+3.362	.002	.002	3	2
BREAST	OR52E2 →	+0.012	+5.169	<.001	.005	3	1
BREAST	OR5H2 →	+0.030	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 710 associations by consensus.

NKX2-6 by PHLDB2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →