PHLDB1

Across TCGA patient cohorts, PHLDB1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,223 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PHLDB1-associated genes across cancer lineages are SRPX, SGCA, and JAM3. Each is linked with PHLDB1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PHLDB1-to-partner and partner-to-PHLDB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHLDB1 versus SRPX in BRCA, with a Pearson correlation of 0.76.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB1→partner) and Y-score (partner→PHLDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRPX →	+1.705	+0.552	<.001	<.001	3	9
HNSC	SGCA →	+1.129	+0.337	<.001	.002	3	9
BRCA	JAM3 →	+1.339	+0.601	<.001	<.001	3	9
BRCA	LHFPL6 →	+1.389	+0.542	<.001	<.001	3	9
BRCA	PARVA →	+0.844	+0.525	<.001	<.001	3	9
UCEC	TIMP3 →	+1.637	+0.470	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,223 associations by consensus.

PHLDB1 vs SRPX — BRCA

Explore this scatter interactively →