PHLDB1

Across TCGA pan-cancer cohorts, PHLDB1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PHLDB1 data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PHLDB1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PHLDB1 expression acts as an unfavorable survival marker, although some lineages such as UCS and LUAD show a favorable association.

ACC, MESO, and KICH are the cancer types where PHLDB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.373	0.814	<.001	119	view →
MESO	DFS	Median	All	0.294	0.479	.002	52	view →
KICH	OS	Median	All	0.750	0.972	.006	44	view →
LUSC	DFS	Quartile	III,IV	0.217	0.603	.001	30	view →
UCS	DFS	Median	IV	0.952	0.367	.001	28	view →
LGG	OS	Median	All	0.757	0.860	.001	28	view →
CESC	DFS	Median	All	0.645	0.822	<.001	26	view →
HNSC	OS	Median	III,IV	0.544	0.807	.002	24	view →
UCEC	DFS	Quartile	All	0.766	0.865	.012	18	view →
UVM	DFS	Tertile	II,III,IV	0.434	0.796	.005	18	view →
LUAD	OS	Tertile	II,III,IV	0.772	0.649	.010	14	view →
COAD	DFS	Median	IV	0.358	0.597	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PHLDB1–ACC (OS)

Open the ACC breakdown →