PHLDB1

Across TCGA patient cohorts, PHLDB1 mutation is significantly associated with the RNA expression of many other genes, with 5,024 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHLDB1-associated genes across cancer lineages are TRAPPC4, SAAL1, and APBA1. Each is linked with PHLDB1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHLDB1-to-partner and partner-to-PHLDB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAPPC4 grouped by PHLDB1-low versus PHLDB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB1→partner) and Y-score (partner→PHLDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAPPC4 →	+0.235	+1.447	.007	.005	3	4
STAD	SAAL1 →	+0.666	+3.476	<.001	.002	3	4
COAD	APBA1 →	-0.436	-3.295	.002	.009	3	3
COAD	ABAT →	-1.076	-2.767	<.001	.003	3	3
COAD	ELAC2 →	+0.370	+2.947	.001	<.001	3	3
COAD	MOCOS →	+0.562	+3.710	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,024 associations by consensus.

TRAPPC4 by PHLDB1 expression — UCEC

Explore this box plot interactively →