PHLDB1

Across TCGA patient cohorts, PHLDB1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHLDB1-associated genes across cancer lineages are FOXO3a_pS318_S321, TFRC, and ASNS. Each is linked with PHLDB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHLDB1-to-partner and partner-to-PHLDB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by PHLDB1-low versus PHLDB1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB1→partner) and Y-score (partner→PHLDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FOXO3a_pS318_S321 →	-0.243	-3.148	.006	.019	3	2
STAD	TFRC →	+0.821	+3.169	.007	.019	2	3
STAD	ASNS →	+0.508	+3.169	.019	.019	3	2
STAD	Cyclin-E2 →	+0.170	+3.190	.010	.009	3	2
UCEC	eEF2 →	+0.223	+1.000	.025	.033	3	2
UCEC	eIF4E →	+0.133	+1.678	.023	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

FOXO3a_pS318_S321 by PHLDB1 expression — STAD

Explore this box plot interactively →