PHLDB1

Across TCGA cell cohorts, PHLDB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,414 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PHLDB1-associated GO terms across cancer lineages are PML body organization, Regulation of cell-substrate junction organization, and Regulation of cell junction assembly. Each is linked with PHLDB1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PHLDB1-to-partner and partner-to-PHLDB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PML body organization grouped by PHLDB1-low versus PHLDB1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB1→partner) and Y-score (partner→PHLDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PML body organization →	+0.195	+1.736	<.001	<.001	3	14
BONE	Regulation of cell-substrate junction organization →	+0.119	+1.471	<.001	<.001	3	14
BONE	Regulation of cell junction assembly →	+0.089	+2.214	<.001	<.001	3	14
BONE	Regulation of focal adhesion assembly →	+0.202	+1.914	<.001	<.001	3	13
BONE	Regulation of cell-substrate junction assembly →	+0.202	+1.914	<.001	<.001	3	13
BONE	Regulation of protein K48-linked ubiquitination →	+0.190	+1.747	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,414 associations by consensus.

PML body organization by PHLDB1 expression — BONE

Explore this box plot interactively →