PHLDB1

Across TCGA cell cohorts, PHLDB1 mutation is significantly associated with the RNA expression of many other genes, with 923 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHLDB1-associated genes across cancer lineages are GOLGA8M, TGFBI, and ZNF644. Each is linked with PHLDB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHLDB1-to-partner and partner-to-PHLDB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOLGA8M grouped by PHLDB1-low versus PHLDB1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB1→partner) and Y-score (partner→PHLDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GOLGA8M →	+0.275	+3.502	<.001	.006	3	2
LARGE_INTESTINE	TGFBI →	-3.089	-2.541	<.001	.005	3	2
LARGE_INTESTINE	ZNF644 →	+0.395	+3.169	.004	.009	3	2
LARGE_INTESTINE	MMACHC →	+0.685	+2.628	.002	.002	3	2
LARGE_INTESTINE	PEMT →	+0.483	+2.714	.006	.002	3	2
LARGE_INTESTINE	DBT →	+0.499	+2.389	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 923 associations by consensus.

GOLGA8M by PHLDB1 expression — BLOOD_Lymphoma

Explore this box plot interactively →