PHLDA3

Across TCGA patient cohorts, PHLDA3 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHLDA3-associated genes across cancer lineages are IQCF5, NF1P10, and RNU6-751P. Each is linked with PHLDA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHLDA3-to-partner and partner-to-PHLDA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by PHLDA3-low versus PHLDA3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDA3→partner) and Y-score (partner→PHLDA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IQCF5 →	+0.132	+6.584	<.001	.001	3	3
UCEC	NF1P10 →	+0.331	+3.778	<.001	.007	3	2
UCEC	RNU6-751P →	+0.416	+6.151	<.001	<.001	3	2
UCEC	MIR6851 →	+1.091	+4.517	<.001	.002	3	1
BRCA	RNA5SP487 →	+0.283	+8.471	<.001	.005	3	1
BRCA	USP9YP2 →	+0.039	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

IQCF5 by PHLDA3 expression — LUAD

Explore this box plot interactively →