PHLDA3

Across TCGA pan-cancer cohorts, PHLDA3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PHLDA3 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher PHLDA3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PHLDA3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SARC show a favorable association.

LGG, UCEC, and SARC are the cancer types where PHLDA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.769	0.889	<.001	50	view →
UCEC	DFS	Quartile	II,III,IV	0.865	0.736	.006	34	view →
SARC	DFS	Median	All	0.665	0.410	<.001	33	view →
LIHC	OS	Quartile	II,III,IV	0.551	0.263	.004	28	view →
KIRP	DFS	Tertile	All	0.532	0.888	.003	24	view →
CHOL	DFS	Quartile	All	0.132	1.000	.001	24	view →
OV	DFS	Median	IV	0.320	0.580	<.001	20	view →
UVM	DFS	Median	All	0.715	0.375	.012	18	view →
KIRC	DFS	Quartile	All	0.397	0.766	.001	18	view →
READ	OS	Quartile	All	0.320	0.799	.007	17	view →
SKCM	OS	Median	II,III,IV	0.676	0.787	.003	12	view →
LUSC	OS	Quartile	All	0.713	0.838	.001	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PHLDA3–LGG (DFS)

Open the LGG breakdown →