PHLDA3

Across TCGA patient cohorts, PHLDA3 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHLDA3-associated genes across cancer lineages are Mesangial cells, CD8+ T-cells, and CD8+ Tcm. Each is linked with PHLDA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHLDA3-to-partner and partner-to-PHLDA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mesangial cells grouped by PHLDA3-low versus PHLDA3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDA3→partner) and Y-score (partner→PHLDA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Mesangial cells →	+0.023	+2.542	.012	.027	3	1
UCEC	CD8+ T-cells →	+0.026	+3.260	.004	.036	3	1
UCEC	CD8+ Tcm →	+0.042	+3.350	.004	.032	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Mesangial cells by PHLDA3 expression — BLCA

Explore this box plot interactively →