PHLDA3

Across TCGA cell cohorts, PHLDA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,203 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PHLDA3-associated GO terms across cancer lineages are Cell-substrate junction organization, Regulation of cardiolipin metabolic process, and Cellular response to cell-matrix adhesion. Each is linked with PHLDA3 in more than 11 cancer types. Because this analysis shows association rather than direction, both PHLDA3-to-partner and partner-to-PHLDA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell-substrate junction organization grouped by PHLDA3-low versus PHLDA3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDA3→partner) and Y-score (partner→PHLDA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Cell-substrate junction organization →	+0.191	+2.898	<.001	<.001	3	12
LIVER	Regulation of cardiolipin metabolic process →	-0.195	-3.954	<.001	<.001	3	12
URINARY_TRACT	Cellular response to cell-matrix adhesion →	+0.245	+1.953	.004	.006	3	11
BONE	Cell-substrate adhesion →	+0.112	+1.266	.001	.004	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of endothelial cell migration →	+0.107	+1.939	<.001	<.001	3	11
BONE	Regulation of protein localization to plasma membrane →	+0.102	+1.352	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,203 associations by consensus.

Cell-substrate junction organization by PHLDA3 expression — URINARY_TRACT

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