PHLDA2

Across TCGA patient cohorts, PHLDA2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PHLDA2-associated genes across cancer lineages are RNA5SP304 and FAM230J. Each is linked with PHLDA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHLDA2-to-partner and partner-to-PHLDA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP304 grouped by PHLDA2-low versus PHLDA2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDA2→partner) and Y-score (partner→PHLDA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP304 →	+0.294	+6.111	<.001	.002	3	1
HNSC	FAM230J →	+0.006	+6.008	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

RNA5SP304 by PHLDA2 expression — HNSC

Explore this box plot interactively →