PHLDA2

Across TCGA cell cohorts, PHLDA2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHLDA2-associated genes across cancer lineages are MSGN1, COX6A2, and TBC1D21. Each is linked with PHLDA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHLDA2-to-partner and partner-to-PHLDA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by PHLDA2-low versus PHLDA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDA2→partner) and Y-score (partner→PHLDA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	C12orf40 →	+0.009	+3.684	<.001	.006	3	1
LARGE_INTESTINE	CCER1 →	+0.013	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	MS4A18 →	+0.023	+4.510	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MSGN1 by PHLDA2 expression — LARGE_INTESTINE

Explore this box plot interactively →