PHLDA2

Across TCGA cell cohorts, PHLDA2 mutation is significantly associated with the mutation status of many other genes, with 1,976 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHLDA2-associated genes across cancer lineages are UGCG, TRPC4AP, and ABHD12. Each is linked with PHLDA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHLDA2-to-partner and partner-to-PHLDA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UGCG grouped by PHLDA2-low versus PHLDA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDA2→partner) and Y-score (partner→PHLDA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UGCG →	+6.321	+6.321	.001	.001	1	3
BLOOD_Leukemia	TRPC4AP →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	ABHD12 →	+4.736	+5.560	.003	.003	1	2
BLOOD_Leukemia	MCF2 →	+4.000	+5.050	.008	.008	1	2
BLOOD_Leukemia	LACTB →	+6.321	+6.321	.001	.001	1	2
BLOOD_Leukemia	RIPK2 →	+6.321	+6.321	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,976 associations by consensus.

UGCG by PHLDA2 expression — BLOOD_Leukemia

Explore this box plot interactively →