PHLDA1

Across TCGA cell cohorts, PHLDA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,592 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PHLDA1-associated GO terms across cancer lineages are Regulation of epidermal growth factor receptor signaling pathway, Positive regulation of focal adhesion assembly, and Cellular response to mechanical stimulus. Each is linked with PHLDA1 in more than 11 cancer types. Because this analysis shows association rather than direction, both PHLDA1-to-partner and partner-to-PHLDA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of epidermal growth factor receptor signaling pathway grouped by PHLDA1-low versus PHLDA1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDA1→partner) and Y-score (partner→PHLDA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of epidermal growth factor receptor signaling pathway →	+0.065	+2.013	<.001	<.001	3	12
BONE	Positive regulation of focal adhesion assembly →	+0.199	+3.084	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Cellular response to mechanical stimulus →	+0.107	+2.300	.003	.005	3	11
BONE	Pyrimidine nucleoside catabolic process →	+1.542	+3.466	<.001	<.001	3	11
BREAST	Positive regulation of transmission of nerve impulse →	+1.542	+3.154	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Cellular response to external stimulus →	+0.118	+2.761	.008	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,592 associations by consensus.

Regulation of epidermal growth factor receptor signaling pathway by PHLDA1 expression — BREAST

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