PHLDA1

Across TCGA pan-cancer cohorts, PHLDA1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PHLDA1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PHLDA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PHLDA1 is over-expressed in tumor, although a few such as LIHC and BRCA show the opposite, repressed pattern.

COAD, KIRC, and LIHC are the cancer types where PHLDA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHLDA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+2.682	<.001	12	view →
KIRC	Male	All	+0.838	<.001	7	view →
LIHC	Female	All	−1.911	<.001	5	view →
LUSC	All	All	+0.650	<.001	5	view →
READ	All	All	+2.782	.001	4	view →
BRCA	Female	II,III,IV	−0.918	<.001	4	view →
LUAD	All	II,III,IV	+0.609	.022	4	view →
THCA	All	All	−0.497	.001	4	view →
BLCA	Female	III,IV	−2.075	.002	3	view →
PAAD	Female	All	+1.605	.003	2	view →
UCEC	All	IV	−1.185	.025	2	view →
PRAD	All	All	−0.937	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PHLDA1–COAD

Open the COAD breakdown →