PHIP

Across TCGA patient cohorts, PHIP RNA expression is significantly associated with the protein abundance of many other proteins, with 17,435 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PHIP-associated proteins across cancer lineages are GATAD2B, POGZ, and SCAF8. Each is linked with PHIP in more than 5 cancer types. Because this analysis shows association rather than direction, both PHIP-to-partner and partner-to-PHIP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHIP versus GATAD2B in HNSC, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PHIP→partner) and Y-score (partner→PHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GATAD2B →	+0.400	+0.802	<.001	<.001	3	6
LSCC	POGZ →	+0.270	+0.467	<.001	<.001	3	6
UCEC	SCAF8 →	+0.213	+0.372	<.001	<.001	3	6
GBM	SMC3 →	+0.296	+0.411	.005	.007	3	6
UCEC	SPAG1 →	-0.686	-0.393	<.001	<.001	3	5
LSCC	AQR →	+0.315	+0.604	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,435 associations by consensus.

PHIP vs GATAD2B — HNSC

Explore this scatter interactively →