PHIP

Across TCGA patient cohorts, PHIP mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHIP-associated genes across cancer lineages are ASNS, eEF2, and TIGAR. Each is linked with PHIP in more than 3 cancer types. Because this analysis shows association rather than direction, both PHIP-to-partner and partner-to-PHIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PHIP-low versus PHIP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHIP→partner) and Y-score (partner→PHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.579	+1.815	<.001	.016	3	4
UCEC	eEF2 →	+0.279	+1.678	.006	.019	3	3
UCEC	TIGAR →	+0.130	+2.392	.002	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.160	-1.940	<.001	<.001	3	2
COAD	14-3-3_beta →	-0.174	-3.131	.022	.018	3	2
UCEC	eIF4E →	+0.164	+2.192	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

ASNS by PHIP expression — COAD

Explore this box plot interactively →