PHIP

Across TCGA cell cohorts, PHIP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,287 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PHIP-associated GO terms across cancer lineages are Centrosome cycle, Regulation of formation of translation preinitiation complex, and Negative regulation of formation of translation preinitiation complex. Each is linked with PHIP in more than 19 cancer types. Because this analysis shows association rather than direction, both PHIP-to-partner and partner-to-PHIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centrosome cycle grouped by PHIP-low versus PHIP-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHIP→partner) and Y-score (partner→PHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Centrosome cycle →	+0.099	+0.946	<.001	<.001	3	20
SKIN	Regulation of formation of translation preinitiation complex →	+0.087	+0.707	.002	.001	3	19
SKIN	Negative regulation of formation of translation preinitiation complex →	+0.087	+0.707	.002	.001	3	19
KIDNEY	Protein localization to condensed chromosome →	+0.145	+0.898	<.001	<.001	3	19
OESOPHAGUS	Positive regulation of mRNA metabolic process →	+0.095	+1.380	<.001	<.001	3	19
URINARY_TRACT	Microtubule organizing center organization →	+0.095	+1.038	<.001	.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,287 associations by consensus.

Centrosome cycle by PHIP expression — BREAST

Explore this box plot interactively →