PHIP

Across TCGA cell cohorts, PHIP protein abundance is significantly associated with the go_rna of many other GO terms, with 3,353 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHIP-associated GO terms across cancer lineages are Cell-matrix adhesion, Regulation of T cell mediated immunity, and CD8-positive, alpha-beta T cell differentiation. Each is linked with PHIP in more than 5 cancer types. Because this analysis shows association rather than direction, both PHIP-to-partner and partner-to-PHIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell-matrix adhesion grouped by PHIP-low versus PHIP-high in STOMACH.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHIP→partner) and Y-score (partner→PHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Cell-matrix adhesion →	+0.187	+3.267	<.001	.001	3	6
BREAST	Regulation of T cell mediated immunity →	+0.100	+1.255	<.001	.003	3	5
BREAST	CD8-positive, alpha-beta T cell differentiation →	+0.127	+1.268	.001	<.001	3	5
BLOOD_Leukemia	Regulation of mucus secretion →	+1.300	+1.960	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	Response to glycoside →	+0.103	+1.577	.006	.003	3	5
STOMACH	Cell-substrate adhesion →	+0.202	+2.744	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,353 associations by consensus.

Cell-matrix adhesion by PHIP expression — STOMACH

Explore this box plot interactively →