PHF8

Across TCGA patient cohorts, PHF8 mutation is significantly associated with the RNA expression of many other genes, with 4,238 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF8-associated genes across cancer lineages are RNA5SP411, RNVU1-28, and SFXN1. Each is linked with PHF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHF8-to-partner and partner-to-PHF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by PHF8-low versus PHF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF8→partner) and Y-score (partner→PHF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+0.480	+1.159	.004	.006	3	3
UCEC	RNVU1-28 →	+0.532	+1.686	<.001	<.001	3	3
UCEC	SFXN1 →	+0.422	+1.357	<.001	<.001	3	3
UCEC	COX10 →	+0.354	+1.485	<.001	<.001	3	3
UCEC	ELAC2 →	+0.354	+1.618	<.001	<.001	3	3
LUAD	MIR3922 →	+0.368	+3.864	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,238 associations by consensus.

RNA5SP411 by PHF8 expression — UCEC

Explore this box plot interactively →