PHF8

Across TCGA pan-cancer cohorts, PHF8 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PHF8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PHF8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PHF8 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

COAD, STAD, and KIRC are the cancer types where PHF8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHF8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.658	<.001	10	view →
STAD	All	II,III,IV	+0.861	<.001	8	view →
KIRC	Male	II,III,IV	−0.518	<.001	6	view →
BRCA	All	II,III,IV	+0.397	<.001	6	view →
LUAD	All	All	+0.385	<.001	6	view →
HNSC	Male	All	+0.531	.015	5	view →
LUSC	All	All	+0.444	<.001	5	view →
UCEC	All	III,IV	+1.042	.035	4	view →
KICH	All	All	−0.690	<.001	4	view →
READ	All	All	+0.611	.010	4	view →
LIHC	Female	III,IV	+0.603	.008	3	view →
PRAD	All	All	+0.702	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PHF8–COAD

Open the COAD breakdown →