PHF8

Across TCGA patient cohorts, PHF8 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF8-associated genes across cancer lineages are EGFR, eIF4E, and CDK1. Each is linked with PHF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF8-to-partner and partner-to-PHF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by PHF8-low versus PHF8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF8→partner) and Y-score (partner→PHF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EGFR →	-0.207	-3.161	.021	.019	3	2
COAD	eIF4E →	+0.265	+2.820	.002	.035	3	2
COAD	CDK1 →	+0.292	+2.820	.001	.035	3	2
UCEC	INPP4B →	-0.267	-1.530	.001	.003	3	2
UCEC	JNK_pT183_Y185 →	-0.167	-1.834	<.001	<.001	3	2
UCEC	Lck →	+0.146	+1.047	.006	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

EGFR by PHF8 expression — COAD

Explore this box plot interactively →