PHF8

Across TCGA cell cohorts, PHF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,130 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHF8-associated GO terms across cancer lineages are Regulation of heterochromatin formation, Regulation of heterochromatin organization, and Negative regulation of heterochromatin organization. Each is linked with PHF8 in more than 19 cancer types. Because this analysis shows association rather than direction, both PHF8-to-partner and partner-to-PHF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of heterochromatin formation grouped by PHF8-low versus PHF8-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF8→partner) and Y-score (partner→PHF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Regulation of heterochromatin formation →	+0.133	+0.548	.001	.005	3	20
LUNG_SCLC	Regulation of heterochromatin organization →	+0.111	+0.816	<.001	<.001	3	19
LUNG_SCLC	Negative regulation of heterochromatin organization →	+0.169	+1.336	<.001	<.001	3	19
LUNG_SCLC	Negative regulation of heterochromatin formation →	+0.169	+1.336	<.001	<.001	3	19
BONE	Negative regulation of chromatin organization →	+0.162	+0.802	<.001	.002	3	18
STOMACH	Regulation of chromatin organization →	+0.110	+0.659	.006	.007	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,130 associations by consensus.

Regulation of heterochromatin formation by PHF8 expression — BLOOD_Myeloma

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