PHF8

Across TCGA cell cohorts, PHF8 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHF8-associated genes across cancer lineages are FGF3, OR51T1, and GSG1L2. Each is linked with PHF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF8-to-partner and partner-to-PHF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF3 grouped by PHF8-low versus PHF8-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF8→partner) and Y-score (partner→PHF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FGF3 →	+0.081	+4.981	<.001	.008	3	1
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR7G1 →	+0.017	+5.266	<.001	.001	3	1
LARGE_INTESTINE	ASPN →	+0.056	+3.841	<.001	<.001	3	1
LARGE_INTESTINE	ACER1 →	+0.069	+2.823	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FGF3 by PHF8 expression — CNS

Explore this box plot interactively →