PHF7

Across TCGA patient cohorts, PHF7 mutation is significantly associated with the RNA expression of many other genes, with 1,066 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHF7-associated genes across cancer lineages are RNU6-553P, TUBGCP5, and LINC00294. Each is linked with PHF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF7-to-partner and partner-to-PHF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-553P grouped by PHF7-low versus PHF7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF7→partner) and Y-score (partner→PHF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-553P →	+0.499	+2.783	.003	.008	3	2
UCEC	TUBGCP5 →	+0.416	+2.119	.003	.003	3	2
UCEC	LINC00294 →	+0.412	+2.606	.006	<.001	3	2
UCEC	HIRIP3 →	+0.431	+2.617	.005	.005	3	2
UCEC	HOMER1 →	+0.582	+3.332	.006	.005	3	2
UCEC	PDZD8 →	+0.764	+2.595	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,066 associations by consensus.

RNU6-553P by PHF7 expression — SKCM

Explore this box plot interactively →