PHF7

Across TCGA cell cohorts, PHF7 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHF7-associated genes across cancer lineages are SLC32A1, TCEAL6, and MFRP. Each is linked with PHF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF7-to-partner and partner-to-PHF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by PHF7-low versus PHF7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF7→partner) and Y-score (partner→PHF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+0.923	+3.901	<.001	.006	3	1
BLOOD_Leukemia	TCEAL6 →	+0.028	+4.133	.004	.003	3	1
BLOOD_Leukemia	MFRP →	+0.135	+4.149	<.001	.003	3	1
SKIN	RGSL1 →	+0.022	+4.977	<.001	.007	3	1
BLOOD_Leukemia	CDH16 →	+0.021	+4.442	.002	.004	2	1
LARGE_INTESTINE	RASGEF1C →	+0.210	+3.333	.008	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SLC32A1 by PHF7 expression — BLOOD_Leukemia

Explore this box plot interactively →