PHF5A

Across TCGA pan-cancer cohorts, PHF5A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PHF5A data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PHF5A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PHF5A expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

COAD, SKCM, and LUAD are the cancer types where PHF5A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.168	0.801	.003	24	view →
SKCM	DFS	Median	II,III,IV	1.000	0.543	.013	17	view →
LUAD	OS	Median	All	0.035	0.812	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PHF5A–COAD (OS)

Open the COAD breakdown →