PHF5A

Across TCGA pan-cancer cohorts, PHF5A RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PHF5A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PHF5A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PHF5A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and BLCA are the cancer types where PHF5A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHF5A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.270	<.001	12	view →
LIHC	All	III,IV	+1.097	<.001	9	view →
BLCA	All	III,IV	+0.730	<.001	9	view →
COAD	Female	II,III,IV	+0.810	<.001	8	view →
THCA	All	II,III,IV	−0.344	<.001	8	view →
STAD	All	II,III,IV	+0.695	<.001	7	view →
LUSC	Female	All	+0.969	<.001	6	view →
KICH	Female	All	−0.965	<.001	5	view →
KIRC	All	All	+0.220	<.001	4	view →
BRCA	All	All	+0.202	<.001	4	view →
CHOL	Male	All	+2.178	<.001	3	view →
READ	Male	All	+1.006	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PHF5A–HNSC

Open the HNSC breakdown →