PHF5A

Across TCGA pan-cancer cohorts, PHF5A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PHF5A data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PHF5A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PHF5A expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

HNSC, COAD, and LSCC are the cancer types where PHF5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.779	0.912	.006	29	view →
COAD	DFS	Median	III,IV	1.000	0.898	.047	6	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.628	.025	6	view →
CCRCC	DFS	Quartile	All	0.450	1.000	.021	3	view →
GBM	OS	Tertile	All	0.553	0.243	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PHF5A–HNSC (OS)

Open the HNSC breakdown →