PHF5A

Across TCGA patient cohorts, PHF5A mutation is significantly associated with the RNA expression of many other genes, with 126 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PHF5A-associated genes across cancer lineages are RNU6-399P, ICMT, and MTRR. Each is linked with PHF5A in more than 1 cancer types. Because this analysis shows association rather than direction, both PHF5A-to-partner and partner-to-PHF5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-399P grouped by PHF5A-low versus PHF5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHF5A→partner) and Y-score (partner→PHF5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-399P →	+0.630	+4.621	<.001	.008	3	2
SKCM	ICMT →	+0.605	+3.240	.003	.009	3	1
SKCM	MTRR →	+0.694	+3.227	.009	.009	3	1
SKCM	TMEM165 →	+0.628	+3.198	.008	.009	3	1
SKCM	UVSSA →	+0.732	+3.198	.001	.009	3	1
SKCM	DDX43 →	+1.494	+3.227	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 126 associations by consensus.

RNU6-399P by PHF5A expression — UCEC

Explore this box plot interactively →